Thymic DCs derived IL-27 regulates the final maturation of CD4+ SP thymocytes
نویسندگان
چکیده
منابع مشابه
Thymic DCs derived IL-27 regulates the final maturation of CD4+ SP thymocytes
IL-27, as a pleiotropic cytokine, promotes the differentiation of naïve T cells to Th1, while suppressing Th2 and Th17 differentiation in the periphery. However, the role of IL-27 in the thymocyte development remains unknown. Here we showed that IL-27 was highly expressed in thymic plasmacytoid dendritic cells (pDCs) while its receptor expression was mainly detected in CD4(+) single-positive (S...
متن کاملThymic exosomes promote the final maturation of thymocytes
Extensive knowledge has been gained the last years concerning mechanisms underlying the selection of single positive thymocytes in the thymic medulla. Less is known regarding other important processes in the thymic medulla such as the regulation of late stage thymocyte maturation. We have previously reported that exosomes are abundant in the thymus with a phenotype that indicates an epithelial ...
متن کاملThe Molecular Signature Underlying the Thymic Migration and Maturation of TCRαβ+CD4+CD8- Thymocytes
BACKGROUND After positive selection, the newly generated single positive (SP) thymocytes migrate to the thymic medulla, where they undergo negative selection to eliminate autoreactive T cells and functional maturation to acquire immune competence and egress capability. METHODOLOGY/PRINCIPAL FINDINGS To elucidate the genetic program underlying this process, we analyzed changes in gene expressi...
متن کاملMaturation and migration of murine CD4 single positive thymocytes and thymic emigrants
T lymphopoiesis in the thymus was thought to be completed once they reach the single positive (SP) stage, when they are "fully mature" and wait to be exported at random or follow a "first in-first out" manner. Recently, accumulating evidence has revealed that newly generated SP thymocytes undergo further maturation in the thymic medulla before they follow a tightly regulated emigrating process ...
متن کاملIL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection.
Control of infection caused by Leishmania major requires the development of IFN-gamma+CD4+ lymphocytes for the induction of microbicidal activity in host macrophages. We recently reported on the inability of conventionally resistant C57BL/6 mice to successfully resolve infection by an isolate of L. major, despite a strong IFN-gamma response by the host. Susceptibility was caused by Ag-specific ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep30448